Over the past decade, structural biology has undergone one of its most profound transformations since the advent of deep learning. What began with single-chain structure prediction has rapidly expanded into a new frontier: co-folding systems capable of modeling interacting biomolecules (protein–protein, protein–ligand, nucleic acids, and higher-order assemblies) with increasing fidelity and scope.

As single-structure prediction matured, the field turned toward harder and more consequential questions: how molecular interfaces form and rearrange, how conformational ensembles encode function, and how interactions reshape energy landscapes in biologically meaningful ways. A new generation of models is now engaging these challenges directly, integrating machine learning, physics, and experimental data to move beyond static structures toward interaction-aware, mechanistically informed representations.

The pace of progress is accelerating. So is the need for deeper, more candid scientific exchange.

The CoFold Summit was created to meet that need. It is an open, international forum designed specifically for researchers building, evaluating, and applying co-folding models outside the constraints of traditional conference tracks and disciplinary silos. The focus is not on polished narratives or product announcements, but on methods, benchmarks, failure modes, and biological relevance.

This meeting is intended to serve both as a meeting ground and a catalyst. The program emphasizes technical depth, live demonstrations, and substantive discussion—bringing together foundational model developers, downstream tool builders, molecular scientists, and the open-source communities that sustain this work. By convening these groups in one place, we aim to accelerate the next phase of progress in folding, interaction prediction, and molecular design.

The inaugural CoFold Summit will take place in Barcelona in 2026, launching a new annual gathering for a rapidly evolving field. Scheduled alongside the long-standing Free Energy Workshop and the OMSF Symposium, it expands the ecosystem into a concentrated week of scientific exchange at the intersection of AI, structure, and molecular discovery.If you are working on co-folding, molecular interactions, or the next generation of structure-based models, we hope you’ll join us.